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Literature summary extracted from

  • Hu, Y.; Xu, W.; Hui, C.; Xu, J.; Huang, M.; Lin, X.; Wu, Q.
    The mutagenesis of a single site for enhancing or reversing the enantio- or regiopreference of cyclohexanone monooxygenases (2020), Chem. Commun. (Camb.), 56, 9356-9359 .
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.13.22 F277I mutation reverses stereoselectivity of wild-type Acinetobacter johnsonii
1.14.13.22 F277P mutation reverses stereoselectivity of wild-type Acinetobacter johnsonii
1.14.13.22 F277V mutation reverses stereoselectivity of wild-type Acinetobacter johnsonii
1.14.13.22 F277W mutation enhances stereoselectivity of wild-type Acinetobacter johnsonii

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.22 Acinetobacter johnsonii P12015
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.22 2-phenylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter johnsonii 1-oxa-2-oxo-3-phenylcycloheptane + NADP+ + H2O
-
 ?
1.14.13.22 3-phenylcyclobutanone+ NADPH + H+ + O2
-
 Acinetobacter johnsonii 3-phenyloxolan-2-one + NADP+ + H2O
-
 ?
1.14.13.22 3-phenylcyclohexanone + NADPH + H+ + O2
-
 Acinetobacter johnsonii 1-oxa-2-oxo-4-phenylcycloheptane + NADP+ + H2O
-
 ?
1.14.13.22 3-phenylcyclopentanone + NADPH + H+ + O2
-
 Acinetobacter johnsonii 4-phenyloxan-2-one + NADP+ + H2O
-
 ?